![](/CAS/GIF/128796-39-4.gif)
4-Trifluoromethylphenylboronic acid synthesis
- Product Name:4-Trifluoromethylphenylboronic acid
- CAS Number:128796-39-4
- Molecular formula:C7H6BF3O2
- Molecular Weight:189.93
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
738 suppliers
$7.29/5ml-f
![Dicyclohexylamine borane 95%](/CAS/20200331/GIF/131765-96-3.gif)
131765-96-3
26 suppliers
$42.79/1g
![4-Bromobenzotrifluoride](/CAS/GIF/402-43-7.gif)
402-43-7
432 suppliers
$6.00/10g
![4-Trifluoromethylphenylboronic acid](/CAS/GIF/128796-39-4.gif)
128796-39-4
427 suppliers
$10.00/5g
Yield:128796-39-4 90%
Reaction Conditions:
Stage #1:dicyclohexylamine borane complex;p-trifluoromethylphenyl bromide with magnesium in tetrahydrofuran at 70;
Stage #2:methanol in tetrahydrofuran at 0; for 1 h;
Stage #3: with hydrogenchloride;water in methanol at 20; for 1 h;
Steps:
Addition under Barbier conditions (procedure A)
General procedure: A solution in THF (4 mL) of DIPAB (863 mg, 7.5 mmol), Mg (182 mg, 7.5 mmol) and arylbromide (5 mmol) was stirred at 70 °C until no starting arylbromide remains (TLC). The reaction mixture was cooled down to 0 °C and quenched slowly with 7 mL of MeOH. After 1h, volatile were removed under reduced pressure and the resulting solid was dissolved in 1N HCl/MeOH (7/3). After 1h at room temperature, 100 mL of AcOEt were added, the organic phase was washed with 1N HCl (30 mL) and brine (3×30 mL). Organic phases were concentrated under reduced pressure yielding a solid which was recrystallized from H2O.
References:
Marciasini, Ludovic D.;Richard, Jimmy;Cacciuttolo, Bastien;Sartori, Guillaume;Birepinte, Melodie;Chabaud, Laurent;Pinet, Sandra;Pucheault, Mathieu [Tetrahedron,2019,vol. 75,# 2,p. 164 - 171]
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121-43-7
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![4-Bromobenzotrifluoride](/CAS/GIF/402-43-7.gif)
402-43-7
432 suppliers
$6.00/10g
![4-Trifluoromethylphenylboronic acid](/CAS/GIF/128796-39-4.gif)
128796-39-4
427 suppliers
$10.00/5g
![4-Bromobenzotrifluoride](/CAS/GIF/402-43-7.gif)
402-43-7
432 suppliers
$6.00/10g
![4-Trifluoromethylphenylboronic acid](/CAS/GIF/128796-39-4.gif)
128796-39-4
427 suppliers
$10.00/5g
![4-Aminobenzotrifluoride](/CAS/GIF/455-14-1.gif)
455-14-1
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$5.00/10g
![4-Trifluoromethylphenylboronic acid](/CAS/GIF/128796-39-4.gif)
128796-39-4
427 suppliers
$10.00/5g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
738 suppliers
$7.29/5ml-f
![BORANE-DIISOPROPYLAMINE](/CAS/20211123/GIF/55124-35-1.gif)
55124-35-1
23 suppliers
$60.00/100mg
![4-Bromobenzotrifluoride](/CAS/GIF/402-43-7.gif)
402-43-7
432 suppliers
$6.00/10g
![4-Trifluoromethylphenylboronic acid](/CAS/GIF/128796-39-4.gif)
128796-39-4
427 suppliers
$10.00/5g