ChemicalBook CAS DataBase List 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID

3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID synthesis

7synthesis methods

Product Name:3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID
CAS Number:40101-51-7
Molecular formula:C15H9NO4
Molecular Weight:267.24

85-44-9 Synthesis

85-44-9
753 suppliers
$9.00/5g

99-05-8
510 suppliers
$14.00/5g

3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID

40101-51-7
40 suppliers
$100.00/100mg

Yield:40101-51-7 94.3%

Reaction Conditions:

with acetic acid at 100; for 3 h;

Steps:

18 Example 18

Add phthalic anhydride (450 mg, 3.0 mmol) and 3-aminobenzoic acid (415 mg, 3.0 mmol) to glacial acetic acid(10 mL), heated to 100 ° C for 3 h. The reaction was quenched with water (10 mL).The pH of the solution was adjusted to 6-8 by a NaOH solution (0.1 mol/L). Dichloromethane extraction (10mL × 3),Wash with saturated NaHCO3 solution, wash with water, and combine with organicAfter drying, 746 mg of a yellow solid was obtained.LC-MS and 1 H-NMR confirmed the expected intermediate compound in a yield of 94.3%.

References:

CN109867661,2019,A Location in patent:Paragraph 0216; 0218