2'-O-(tert-Butyldimethylsilyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine synthesis

4synthesis methods

Product Name:2'-O-(tert-Butyldimethylsilyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine
CAS Number:401812-99-5
Molecular formula:C24H43N5O5Si2
Molecular Weight:537.8

Guanosine, 3',5'-O-[bis(1,1-dimethylethyl)silylene]-

126628-29-3
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18162-48-6 Synthesis

18162-48-6
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$9.00/5g

2'-O-(tert-Butyldimethylsilyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine

401812-99-5
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$722.00/1g

Yield:401812-99-5 87.4%

Reaction Conditions:

Stage #1: 2-amino-9-((4aR,6R,7R,7aS)-2,2-di-tert-butyl-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl)-1,9-dihydro-6H-purin-6-onewith 1H-imidazole in N,N-dimethyl-formamide at 0 - 25; for 1 h;
Stage #2: tert-butyldimethylsilyl chloride at 60; for 2 h;

References:

Serebryany, Vladimir;Beigelman, Leonid [Tetrahedron Letters,2002,vol. 43,# 11,p. 1983 - 1985]

85272-31-7 Synthesis