ChemicalBook CAS DataBase List trans-4-Hydroxy-L-proline methyl ester hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride synthesis

6synthesis methods

Product Name:trans-4-Hydroxy-L-proline methyl ester hydrochloride
CAS Number:40216-83-9
Molecular formula:C6H12ClNO3
Molecular Weight:181.62

67-56-1 Synthesis

67-56-1
751 suppliers
$7.29/5ml-f

13726-69-7
434 suppliers
$5.00/1g

trans-4-Hydroxy-L-proline methyl ester hydrochloride

40216-83-9
318 suppliers
$6.00/5g

Yield:40216-83-9 99%

Reaction Conditions:

with hydrogenchloride at 20; for 12 h;

Steps:

Compound 20r (2 g, 8.6 mmol) was taken up with a solution of HC1 (g) in methanol (4 M, 40 mL). The mixture was stirred at ambient temperature for 12 hrs. After that, the reaction mixture was concentrated under reduced pressure to afford compound 20s (1.6 g, yield 99%) as a white solid.

References:

INTERMUNE, INC.;BUCKMAN, Brad;NICHOLAS, John, B.;SEREBRYANY, Vladimir;SEIWERT, Scott, D. WO2012/37259, 2012, A1 Location in patent:Page/Page column 74

FullText

67-56-1 Synthesis

67-56-1
751 suppliers
$7.29/5ml-f

32968-78-8 Synthesis