2-Amino-1-benzo[1,3]dioxol-5-yl-ethanol hydrochloride synthesis

Yield:-

Reaction Conditions:

palladium-carbon in methanol;ethyl acetate;

Steps:

A 1-(3,4-METHYLENEDIOXYPHENYL)-2-AMINOETHANOL HYDROCHLORIDE

EXAMPLE A 1-(3,4-METHYLENEDIOXYPHENYL)-2-AMINOETHANOL HYDROCHLORIDE 10.5 g. of 1-(3,4-methylenedioxyphenyl)-2-nitroethanol are dissolved in 150 ml. of methanol and to the solution is added 1 g. of palladium carbon. The resulting mixture is hydrogenolyzed with vigorous stirring. After the absorption of hydrogen is complete, the stirring is discontinued and the catalyst is filtered off and the filtrate is concentrated to dryness. The residue is dissolved in ethyl acetate and ethyl acetate acidified with hydrochloric acid is added to the solution until the white turbidity ceases to form. The crystals which form on standing are filtered off and washed thoroughly with ethyl acetate. Upon recrystallization from isopropyl alcohol, 8.3 g. of 1-(3,4-methylenedioxyphenyl)-2-aminoethanol hydrochloride are obtained. Melting point: 181°-182° C. Elementary analysis: as C₉ H₁₁ NO₃.HCl; Calculated: C= 49.65, H= 5.51, N= 6.43; Found: C= 49.73, H= 5.57, N= 6.32.

References:

US4147799,1979,A