ChemicalBook CAS DataBase List 5-fluoro-2-chlorosulfonyl-3-Methylbenzo[b]thiophene

5-fluoro-2-chlorosulfonyl-3-Methylbenzo[b]thiophene synthesis

3synthesis methods

Product Name:5-fluoro-2-chlorosulfonyl-3-Methylbenzo[b]thiophene
CAS Number:404964-34-7
Molecular formula:C9H6ClFO2S2
Molecular Weight:264.72

Benzo[b]thiophene-2-sulfonic acid, 5-fluoro-3-methyl-

1353433-16-5
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5-fluoro-2-chlorosulfonyl-3-Methylbenzo[b]thiophene

404964-34-7
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$138.00/1g

Yield:404964-34-7 93%

Reaction Conditions:

with trichlorophosphate at 60;

Steps:

10

Intermediate 10-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonyl chlorideA solution of commercially available 5-fluoro-3-methyl-l-benzothiophene (215 mg, 1.29 mmol), Ac₂0 (365 μ, 3.86 mmol) and cone. H₂SO₄ (83 μ) in EtOAc (4 mL) was shaken over night at room temp. The reaction mixture was diluted with EtOAc, washed with H₂0 and Brine and then dried. Evaporation of the solvent afforded 234 mg of 5-fluoro-3-methyl- benzo[b]thiophene-2-sulfonic acid (yield 74%). 1H NMR (400 MHz, DMSO-d₆) δ ppm 2.45 (s, 3 H) 7.22 (td, 1 H) 7.52 (dd, 1 H) 7.89 (dd, 1 H).A mixture of 5-fluoro-3-methylbenzothiophene-2-sulfonic acid (230 mg, 0.93 mmol) in POCI₃ (5 mL) was heated at 60 °C over night. The POCI₃ was evaporated and the crude prod- uct was dissolved in CH₂C1₂ and washed with water. The organic phase was dried and evaporated and gave 0.23 g (93%) of the title compound.

References:

WO2011/161201,2011,A1 Location in patent:Page/Page column 73

17514-63-5 Synthesis

17514-63-5
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404964-34-7
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$138.00/1g

References

2968-13-0
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$26.39/1g

404964-34-7
18 suppliers
$138.00/1g

References