1H-Inden-1-one, 5-[2-[4-[2-(diMethylaMino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-iMidazol-4-yl]-2,3-dihydro- synthesis

Yield:405554-54-3 23%

Reaction Conditions:

with hydrogenchloride;water in 1,4-dioxane at 80;

References:

Niculescu-Duvaz, Dan;Niculescu-Duvaz, Ion;Suijkerbuijk, Bart M.J.M.;Ménard, Delphine;Zambon, Alfonso;Nourry, Arnaud;Davies, Lawrence;Manne, Helen A.;Friedlos, Frank;Ogilvie, Lesley;Hedley, Douglas;Takle, Andrew K.;Wilson, David M.;Pons, Jean-Francois;Coulter, Tom;Kirk, Ruth;Cantarino, Neus;Whittaker, Steven;Marais, Richard;Springer, Caroline J. [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 18,p. 6934 - 6952] Location in patent:experimental part