piperidin-4-yl(pyridin-2-yl)methanone hydrochloride synthesis

4synthesis methods

Product Name:piperidin-4-yl(pyridin-2-yl)methanone hydrochloride
CAS Number:416852-20-5
Molecular formula:C11H15ClN2O
Molecular Weight:226.7026

tert-butyl 4-picolinoylpiperidine-1-carboxylate

416852-19-2
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piperidin-4-yl(pyridin-2-yl)methanone hydrochloride

416852-20-5
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Yield:416852-20-5 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;methanol at 20; for 1.5 h;

Steps:

6.4

A solution of 27 (3.3 g, 11.4 mmol) in methanol (50 mL) was treated with 4M HCl in dioxane (50 mL) and stirred at room temperature for 1.5 h. Removal of the solvent in vacuo gave 28 as a tan powder (3g, 100%)

References:

WO2008/108957,2008,A2 Location in patent:Page/Page column 39

498-94-2 Synthesis

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References

84358-13-4 Synthesis

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References

139290-70-3 Synthesis

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine

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References