3-d)pyrimidin-4(3h)-one,3-amino-2-methyl-5-phenyl-thieno( synthesis

3synthesis methods

Product Name:3-d)pyrimidin-4(3h)-one,3-amino-2-methyl-5-phenyl-thieno(
CAS Number:43088-51-3
Molecular formula:C13H11N3OS
Molecular Weight:257.31

2-methyl-5-phenyl-4H-thieno[2,3-d][1,3]oxazin-4-one

13130-45-5
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3-d)pyrimidin-4(3h)-one,3-amino-2-methyl-5-phenyl-thieno(

43088-51-3
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Yield:43088-51-3 77%

Reaction Conditions:

with hydrazine hydrate in ethanol; for 6 h;Reflux;

Steps:

Synthesis of 3-amino-2-methyl-5-phenyl-3H-thieno-[2,3-d]pyrimidin-4-one (4)

A mixture of 2-methyl-5-phenyl-thieno[2,3-d][1,3]oxazin-4-one (3) (0.01 mL) and hydrazine hydrate (0.05 mol) in ethanol (10 mL) was prepared at room temperature. Then the reaction mixture was heated at reflux temperature on uniform stirring for 6 h. After achievement of the reaction (scanned by the TLC), the resulted mixture cooled and precipitated after poured in ice-cold water. The crude product was filtered and washed with cold water, dried and recrystallized with ethanol to get pure 3-amino-2-methyl-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one (4).

References:

Pullarao;Khasim Sharif;Ravi Kumar;Ramachandran [Asian Journal of Chemistry,2016,vol. 28,# 9,p. 1997 - 2000]

13130-37-5 Synthesis

ethyl 2-acetamido-4-phenylthiophene-3-carboxylate

13130-37-5
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43088-51-3
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4815-36-5 Synthesis

2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

4815-36-5
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$10.00/250mg

43088-51-3
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References