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3,5-Dioxo-2-phenyl-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid synthesis
- Product Name:3,5-Dioxo-2-phenyl-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid
- CAS Number:4315-71-3
- Molecular formula:C10H7N3O4
- Molecular Weight:233.18
![1,2,4-Triazine-6-carbonitrile, 2,3,4,5-tetrahydro-3,5-dioxo-2-phenyl-](/CAS/GIF/20932-00-7.gif)
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![3,5-Dioxo-2-phenyl-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid](/CAS/20180601/GIF/4315-71-3.gif)
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Yield:4315-71-3 47%
Reaction Conditions:
with hydrogenchloride;water;acetic acid at 120; for 4 h;
Steps:
48.Z-a N-[3-fluoro-4-[6-methoxy-7-[3-(1-pyrrolidyl)propyloxy]quinolin]-4-oxy]phenyl]-2-(2,4-dichlorophenyl)-3,5-dicarbonyl-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide Step Z-a 2-phenyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxylic acid (l)
Step Z-a 2-phenyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxylic acid (l)Intermediate c (7.5 g, 0.035 mol) was added to a mixed solvent of glacial acetic acid (100 mL) and HCl (72 mL, 0.86 mol).
The mixture was warmed up to 120° C. and reacted under reflux for 4 h.
The solvent was evaporated off.
To the obtained fraction was added water (200 mL).
The mixture was filtered by suction and dried to produce Intermediate h (3.2 g) in a yield of 47%.
References:
US2013/252958,2013,A1 Location in patent:Paragraph 0165
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![3,5-Dioxo-2-phenyl-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid](/CAS/20180601/GIF/4315-71-3.gif)
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![3,5-Dioxo-2-phenyl-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid](/CAS/20180601/GIF/4315-71-3.gif)
4315-71-3
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