Methyl 2,3,4-tris-O-(phenylmethyl)-beta-D-glucopyranosiduronic acid synthesis

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C
3: iron(III) chloride hexahydrate; triethylsilane / dichloromethane
4: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane; water / 0 - 20 °C

References:

Wan, I. C. Steven;Witte, Martin D.;Minnaard, Adriaan J. [Organic Letters,2019,vol. 21,# 18,p. 7669 - 7673]