N-(1-(3-(3,4-diMethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)ethyl)acetaMide synthesis

Yield:-

Reaction Conditions:

with hydrazine hydrate

Steps:

14.A N-{1-[3-(3,4-Dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide

EXAMPLE 14A N-{1-[3-(3,4-Dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide Analogously to Example 10A, 20.0 g (86.7 mmol) of 2-(3,4-dimethoxyphenyl)ethanamidine hydrochloride are reacted with 5.21 g (104 mmol) of hydrazine hydrate and 24.3 g (130 mmol) of ethyl 3-(acetylamino)-2-oxobutanoate to give N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide. Yield: 15.5 g (77.5% of th.) ¹H-NMR (methanol-d₄): δ/ppm 1.40 (d, 3 H), 1.95 (s, 3 H), 3.78 (s, 3 H), 3.81 (s, 3 H), 3.82 (s, 2 H), 5.16 (q, 1 H), 6.86-6.97 (m, 3 H).

References:

US2002/198377,2002,A1