11-OXO-11H-PYRIDO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID synthesis
- Product Name:11-OXO-11H-PYRIDO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID
- CAS Number:4393-98-0
- Molecular formula:C13H8N2O3
- Molecular Weight:240.21
2942-59-8
792 suppliers
$5.00/25g
134-20-3
583 suppliers
$16.00/25mL
4393-98-0
8 suppliers
$378.00/1g
Yield:4393-98-0 54%
Reaction Conditions:
with hydrogenchloride in ethanol;water at 80; for 48 h;
Steps:
Intermediate 9: 11-oxo-11H-pyrido[2.1-b]quinazoline-6-carboxylic acid
A mixture of methyl 2-aminobenzoate (500 mg, 3.3 mmol), 2-chloronicotinic acid (521 mg, 3.3 mmol) and hydrochloric acid (0.54 mL, 17.8 mmol) in ethanol (8 mL) was stirred at 80° C. for 48 hours.
After cooling, the suspension was filtered, washed with cool ethanol and n-pentane and dried. 54% yield.
1H-RMN (400 MHz, DMSO-d6): δ=9.09 (dd, 1H), 8.68 (dd, 1H), 8.35 (dd, 1H), 8.02 (ddd, 1H), 7.90 (m, 1H), 7.63 (ddd, 1H), 7.32 (t, 1H).
HPLC-MS: Rt: 1.100 min, m/z: 240.9 (MH+).
References:
US2020/79773,2020,A1 Location in patent:Paragraph 0234-0237
2942-59-8
792 suppliers
$5.00/25g
87-25-2
228 suppliers
$19.00/25mL
4393-98-0
8 suppliers
$378.00/1g