ChemicalBook CAS DataBase List TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE

TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE synthesis

9synthesis methods

Product Name:TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE
CAS Number:455267-29-5
Molecular formula:C12H24N2O2
Molecular Weight:228.33

206989-61-9 Synthesis

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

206989-61-9
218 suppliers
$10.00/1g

TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE

455267-29-5
55 suppliers
$146.66/0.25g

Yield:455267-29-5 100%

Reaction Conditions:

Stage #1: 4-acetyl-1-(t-butoxycarbonyl)piperidinewith ammonium acetate;acetic acid in methanol at 25; for 2 h;
Stage #2: with sodium cyanoborohydride in methanol at 25; for 16 h;

Steps:

1.3 Synthesis of tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate

To a solution of tert-butyl 4-acetylpiperidine-1-carboxylate (7.9 g, 34.8 mmol) in MeOH (100 mL) was added NH₄OAc (10.72 g, 139.2 mmol) and AcOH (1 mL). The mixture was stirred at 25 C for 2 h, then was added NaBH₃CN (2.63 g, 41.76 mmol). The mixture was stirred at 25 C for 16 h. The mixture was evaporated and 2N NaOH (50 mL) was added to the residue. The solution was extracted with DCM (100 mL x 3 ). The DCM layer was washed with H₂O and brine dried and evaporated to give the tert-butyl 4- (1-aminoethyl)piperidine-1-carboxylate (7.93 g, yield: 100 %)

References:

KR2017/45749,2017,A Location in patent:Paragraph 0614; 0623-0625