Benzenesulfonamide, N,N-dimethyl-4-(1-piperazinyl)- synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: Cs₂CO₃; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere
2: tripotassium phosphate tribasic; 2-hydroxyethanethiol / N,N-dimethyl acetamide / 24 h / 75 °C / Inert atmosphere

References:

Scattolin, Thomas;Gharbaoui, Tawfik;Chen, Cheng-Yi [Organic Letters,2022,vol. 24,# 20,p. 3736 - 3740]