ChemicalBook CAS DataBase List 9-Oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid, 1,1-dimethylethyl ester

9-Oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid, 1,1-dimethylethyl ester synthesis

2synthesis methods

Product Name:9-Oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid, 1,1-dimethylethyl ester
CAS Number:478647-20-0
Molecular formula:C11H20N2O3
Molecular Weight:228.29

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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9-Oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid, 1,1-dimethylethyl ester

478647-20-0
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$45.00/2.5mg

Yield: 38%

Reaction Conditions:

with hydrogen;palladium(II) hydroxide in methanol

Steps:

1
3-(Benzyloxycarbonyl)-7-(t-butoxycarbonyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonane (0.0041 mol, 1.5 g) in methanol (80 ml.) was hydrogenated over palladium hydroxide. The solution filtered and concentrated to give 1.2 g of crude product. This was dissolved in ethanol and purified by HPLC to yield 0.36 g (38%) of 3- 1- butoxycarbonyl-9-oxa-3,7-diazabicyclo[3.3.1]nonane.

References:

Location in patent:Page/Page column 30

tert-butyl 7-benzyl-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

335620-98-9
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478647-20-0
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$45.00/2.5mg

References