ChemicalBook CAS DataBase List 1-isopropyl-4-(4-isopropylphenyl)-6-Methoxyquinazolin-2(1H)-one

1-isopropyl-4-(4-isopropylphenyl)-6-Methoxyquinazolin-2(1H)-one synthesis

1synthesis methods

Product Name:1-isopropyl-4-(4-isopropylphenyl)-6-Methoxyquinazolin-2(1H)-one
CAS Number:478963-62-1
Molecular formula:C21H24N2O2
Molecular Weight:336.43

75-30-9
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Methanone, (2-amino-5-methoxyphenyl)[4-(1-methylethyl)phenyl]-

478964-53-3
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917-61-3 Synthesis

917-61-3
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1-isopropyl-4-(4-isopropylphenyl)-6-Methoxyquinazolin-2(1H)-one

478963-62-1
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Yield:478963-62-1 150 mg

Reaction Conditions:

Stage #1: 2-iodo-propane;(2-amino-5-methoxyphenyl)-(4-isopropylphenyl)methanonewith potassium carbonate at 110; for 48 h;
Stage #2: sodium isocyanatewith acetic acid at 20;

References:

Widler, Leo;Altmann, Eva;Beerli, René;Breitenstein, Werner;Bouhelal, Rochdi;Buhl, Thomas;Gamse, Rainer;Gerspacher, Marc;Halleux, Christine;John, Markus R.;Lehmann, Hansjoerg;Kalb, Oskar;Kneissel, Michaela;Missbach, Martin;Müller, Irene R.;Reidemeister, Sibylle;Renaud, Johanne;Taillardat, Agnes;Tommasi, Ruben;Weiler, Sven;Wolf, Romain M.;Seuwen, Klaus [Journal of Medicinal Chemistry,2010,vol. 53,# 5,p. 2250 - 2263] Location in patent:experimental part