1-Oxa-2,8-diazaspiro[4.5]dec-2-ene-3,8-dicarboxylic acid, 8-(1,1-diMethylethyl) ester synthesis

2synthesis methods

Product Name:1-Oxa-2,8-diazaspiro[4.5]dec-2-ene-3,8-dicarboxylic acid, 8-(1,1-diMethylethyl) ester
CAS Number:479636-66-3
Molecular formula:C13H20N2O5
Molecular Weight:284.31

479636-65-2 Synthesis

8-tert-butyl 3-ethyl 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3,8-dicarboxylate

479636-65-2
32 suppliers
$75.00/100mg

1-Oxa-2,8-diazaspiro[4.5]dec-2-ene-3,8-dicarboxylic acid, 8-(1,1-diMethylethyl) ester

479636-66-3
30 suppliers
$125.00/100mg

Yield:479636-66-3 98%

Reaction Conditions:

Stage #1: 8-(tert-butyl) 3-ethyl 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3,8-dicarboxylatewith methanol;lithium hydroxide;water monomer at 20; for 1.5 h;
Stage #2: with water monomer;citric acid pH=4;

References:

WO2006/122769,2006,A2 Location in patent:Page/Page column 60-61

159635-49-1 Synthesis

tert-Butyl 4-methylenepiperidine-1-carboxylate

159635-49-1
247 suppliers
$5.00/250mg

479636-66-3
30 suppliers
$125.00/100mg

References