Methyl 4-(3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)benzoate synthesis
- Product Name:Methyl 4-(3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)benzoate
- CAS Number:480390-86-1
- Molecular formula:C17H11F3N2O3
- Molecular Weight:348.28
22179-86-8
84 suppliers
$15.00/1g
7377-26-6
206 suppliers
$7.00/5g
480390-86-1
8 suppliers
$341.00/250mg
Yield:480390-86-1 87%
Reaction Conditions:
with pyridine in water;
Steps:
40 Example 40
Example 40 A mixture of methyl 4-chloroformylbenzoate (1.95 g), 4-trifluoromethylphenyl amidoxime (2.00 g) and pyridine (25 ml) was heated under reflux for 1 hr. After cooling, water was added to the mixture. The crystals were collected by filtration and purified by silica gel column chromatography (hexane:tetrahydrofuran=1:9, volume ratio) to give methyl 4-[3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol-5-yl]benzoate (2.98 g, yield 87%). Recrystallization from hexane-tetrahydrofuran gave colorless crystals. melting point: 177-178°C.
References:
EP1405636,2004,A1
1679-64-7
343 suppliers
$5.00/5g
22179-86-8
84 suppliers
$15.00/1g
480390-86-1
8 suppliers
$341.00/250mg