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3-(4-NITRO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER synthesis

3synthesis methods
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Yield:487034-01-5 36%

Reaction Conditions:

Stage #1: Dimethyl oxalate;1-(4-nitrophenyl)ethan-1-onewith sodium methoxide in methanol; for 12 h;Heating;
Stage #2: with hydroxyamino hydrochloride;toluene-4-sulfonic acid in methanol; for 72 h;Heating;

References:

Srinivasan, Rajavel;Uttamchandani, Mahesh;Yao, Shao Q. [Organic Letters,2006,vol. 8,# 4,p. 713 - 716]

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