ChemicalBook CAS DataBase List tert-butyl(4-(3-(dimethoxyphosphoryl)-2-oxopropyl)phenyl)carbamate

tert-butyl(4-(3-(dimethoxyphosphoryl)-2-oxopropyl)phenyl)carbamate synthesis

2synthesis methods

Product Name:tert-butyl(4-(3-(dimethoxyphosphoryl)-2-oxopropyl)phenyl)carbamate
CAS Number:494224-44-1
Molecular formula:C16H24NO6P
Molecular Weight:357.34

Carbamic acid, N-[4-[2-(methoxymethylamino)-2-oxoethyl]phenyl]-, 1,1-dimethylethyl ester

1189399-11-8
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756-79-6 Synthesis

756-79-6
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$15.00/10g

tert-butyl(4-(3-(dimethoxyphosphoryl)-2-oxopropyl)phenyl)carbamate

494224-44-1
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Yield:494224-44-1 92%

Reaction Conditions:

Stage #1: C₁₅H₂₂N₂O₄;dimethyl methane phosphonatewith lithium diisopropyl amide in tetrahydrofuran at -5 - 0;Inert atmosphere;
Stage #2: with hydrogenchloride in tetrahydrofuran;water; pH=ca. 4;

References:

Maloney, Kevin M.;Chung, John Y. L. [Journal of Organic Chemistry,2009,vol. 74,# 19,p. 7574 - 7576] Location in patent:supporting information; experimental part

METHYL 2-(4-(TERT-BUTOXYCARBONYLAMINO)PHENYL)ACETATE

112918-77-1
23 suppliers
$1072.00/5g

756-79-6 Synthesis

756-79-6
7 suppliers
$15.00/10g

494224-44-1
27 suppliers
inquiry

References