5-(2-BROMOPHENYL)-5-OXOVALERONITRILE synthesis
- Product Name:5-(2-BROMOPHENYL)-5-OXOVALERONITRILE
- CAS Number:884504-59-0
- Molecular formula:C11H10BrNO
- Molecular Weight:252.11
7154-66-7
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Yield:884504-59-0 70%
Reaction Conditions:
Stage #1: 4-bromobutanenitrilewith magnesium;lithium chloride;zinc(II) chloride in tetrahydrofuran at 20; for 1 h;Inert atmosphere;
Stage #2: with copper(I) cyanide di(lithium chloride) in tetrahydrofuran at -30;Inert atmosphere;
Stage #3: 2-bromobenzoic acid chloride in tetrahydrofuran at -30;Inert atmosphere;
References:
Bluemke, Tobias D.;Piller, Fabian M.;Knochel, Paul [Chemical Communications,2010,vol. 46,# 23,p. 4082 - 4084] Location in patent:supporting information; experimental part