5-(2-IODO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE synthesis
- Product Name:5-(2-IODO-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE
- CAS Number:299934-10-4
- Molecular formula:C8H6IN3S
- Molecular Weight:303.12
88-67-5
530 suppliers
$5.00/5g
79-19-6
486 suppliers
$14.00/1g
299934-10-4
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$75.00/250mg
Yield:299934-10-4 98.9%
Reaction Conditions:
with choline chloride;urea at 80; for 2 h;
Steps:
5.1-5.3 Example 5Preparation of 2-amino-5- (2-iodophenyl) -1,3,4-thiadiazole
In the first step, 1 mol of choline chloride and 2 mol of urea are added to the reaction vessel.Stir at 80 ° C until fully dissolved to obtain a eutectic solvent;In the second step, after the reaction system is cooled to room temperature, 1 mol of o-iodobenzoic acid and 1.2 mol of thiosemicarbazide are added, the temperature is slowly raised, and the reaction is refluxed at 80 ° C for 2 hours.TLC monitors the end of the reaction;In the third step, the reaction mixture is cooled to room temperature, and then the pH value is adjusted to 8-9 with a 10% aqueous ammonia solution under ice-cooling, a solid is precipitated, filtered with suction, and the filter cake is washed with ice waterDrying to give 2-amino-5- (2-iodophenyl) -1,3,4-thiadiazole in a yield of 98.9%. The filtrate was recovered to obtain a eutectic solvent.
References:
CN110724115,2020,A Location in patent:Paragraph 0066-0072