5-(2-METHOXY-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID synthesis

5synthesis methods

Product Name:5-(2-METHOXY-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID
CAS Number:668971-16-2
Molecular formula:C11H9NO4
Molecular Weight:219.19

5-(2-METHOXYPHENYL)-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER

110578-28-4
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5-(2-METHOXY-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID

668971-16-2
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$65.00/50mg

Yield:668971-16-2 68%

Reaction Conditions:

with sodium hydroxide in ethanol at 20; for 24 h;

Steps:

2 4.1.4. General procedure for the preparation of 5-arylisoxazole-3-carboxylic acids (33-43)

General procedure: To a stirred solution of ester 22-32 (1 equiv) in 95% EtOH (50 mL), was added sodium hydroxide in pellets (10 equiv). The mixture was stirred at room temperature for 24 h. EtOH was removed under reduced pressure and the residue was acidified (1 N HCl, pH 2) and extracted with EtOAc (220 mL). The organic layers were washed with water (20 mL) and brine (20 mL), dried over MgSO₄ and evaporated under reduced pressure to afford pure carboxylic acids 33-43.

References:

Tourteau, Aurélien;Andrzejak, Virginie;Body-Malapel, Mathilde;Lemaire, Lucas;Lemoine, Amélie;Mansouri, Roxane;Djouina, Madjid;Renault, Nicolas;El Bakali, Jamal;Desreumaux, Pierre;Muccioli, Giulio G.;Lambert, Didier M.;Chavatte, Philippe;Rigo, Beno?t;Leleu-Chavain, Natascha;Millet, Régis [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 17,p. 5383 - 5394]

579-74-8 Synthesis