5-(2-METHOXYPHENYL)-1,3,4-OXADIAZOLE-2-THIOL synthesis

6synthesis methods

Product Name:5-(2-METHOXYPHENYL)-1,3,4-OXADIAZOLE-2-THIOL
CAS Number:69844-25-3
Molecular formula:C9H8N2O2S
Molecular Weight:208.24

75-15-0
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7466-54-8 Synthesis

7466-54-8
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$9.00/5g

5-(2-METHOXYPHENYL)-1,3,4-OXADIAZOLE-2-THIOL

69844-25-3
25 suppliers
$60.00/50mg

Yield: 68%

Reaction Conditions:

in N,N-dimethyl-formamide at 40 - 70;Inert atmosphere;

Steps:

4.9 4.1.2. General procedure for synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols
General procedure: To a solution of acid hydrazide in anhydrous 5-15mL of DMF, carbon disulfide (2.5mL/mmol) was added at room temperature and under a nitrogen atmosphere. The reaction mixture was then heated to 40°C for 15min and then to 70°C for 4-8h until the reaction was completed. After completion, the reaction mixture was cooled to room temperature and poured dropwise into ice cold water. The solids formed were separated by filtration, washed with water and dried in vacuo.

References:

Kummari, Lalith K.;Butler, Mark S.;Furlong, Emily;Blundell, Ross;Nouwens, Amanda;Silva, Alberto B.;Kappler, Ulrike;Fraser, James A.;Kobe, Bostjan;Cooper, Matthew A.;Robertson, Avril A.B. [Bioorganic and Medicinal Chemistry,2018,vol. 26,# 20,p. 5408 - 5419]

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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69844-25-3
25 suppliers
$60.00/50mg

References

606-45-1 Synthesis

606-45-1
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69844-25-3
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$60.00/50mg

References

579-75-9 Synthesis

579-75-9
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$5.00/1g

69844-25-3
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$60.00/50mg

References

7335-26-4 Synthesis

7335-26-4
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$18.00/5g

69844-25-3
25 suppliers
$60.00/50mg

References