5-(2-(METHYLTHIO)PHENYL)-5-OXOVALERIC ACID synthesis
1synthesis methods
- Product Name:5-(2-(METHYLTHIO)PHENYL)-5-OXOVALERIC ACID
- CAS Number:930116-83-9
- Molecular formula:C12H14O3S
- Molecular Weight:238.31
Yield:930116-83-9 60%
Reaction Conditions:
Stage #1: 2-bromo-1-(methylsulfanyl)benzenewith iodine;magnesium in tetrahydrofuran; for 3.66667 h;
Stage #2: glutaric anhydride, in tetrahydrofuran at -40 - 20;
References:
Kooistra, Floris B.;Knol, Joop;Kastenberg, Fredrik;Popescu, Lacramioara M.;Verhees, Wiljan J. H.;Kroon, Jan M.;Hummelen, Jan C. [Organic Letters,2007,vol. 9,# 4,p. 551 - 554]