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ChemicalBook CAS DataBase List 5-(3,5-difluorobenzyl)-2-fluorobenzonitrile

5-(3,5-difluorobenzyl)-2-fluorobenzonitrile synthesis

2synthesis methods
214210-21-6 Synthesis
3-Cyano-4-fluorobenzeneboronic acid

214210-21-6
218 suppliers
$17.00/250mg

141776-91-2 Synthesis
3,5-Difluorobenzyl bromide

141776-91-2
239 suppliers
$5.00/1g

5-(3,5-difluorobenzyl)-2-fluorobenzonitrile

1108745-25-0
48 suppliers
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Yield: 85%

Reaction Conditions:

with potassium phosphate;tetrakis(triphenylphosphine) palladium(0) in toluene at 100;Inert atmosphere;Suzuki-Miyaura coupling;

References:

Orsini, Paolo;Menichincheri, Maria;Vanotti, Ermes;Panzeri, Achille [Tetrahedron Letters,2009,vol. 50,# 25,p. 3098 - 3100] Location in patent:body text