5-(3-Azetidinyl)-2H-tetrazole hydrochloride synthesis

Yield:950691-49-3 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;methanol at 20;

Steps:

33

To a stirred solution of the title compound of preparation 32 (173 mg, 0.77 mmol) in methanol (6 ml), 2 ml of HCI 4M in dioxane were added and the mixture was stirred at room temperature overnight. Solvent was removed in vaccuo and the title compound obtained as hydrochloride.(100% yield)LRMS: m/z 126 (M+1)⁺ Retention time: 0.53 (method B)

References:

WO2011/35900,2011,A1 Location in patent:Page/Page column 49