5-[3-(TRIFLUOROMETHYL)PHENYL]NICOTINIC ACID synthesis
1synthesis methods
- Product Name:5-[3-(TRIFLUOROMETHYL)PHENYL]NICOTINIC ACID
- CAS Number:893740-46-0
- Molecular formula:C13H8F3NO2
- Molecular Weight:267.2
Yield:893740-46-0 87%
Reaction Conditions:
Stage #1: 3-(trifluoromethyl)phenylmagnesium bromidewith titanium(IV) tetraethanolate in tetrahydrofuran at 20; for 0.5 h;Inert atmosphere;
Stage #2: 5-bromo-3-pyridinecarboxylic acidwith tributylphosphine;cobalt(II) chloride in tetrahydrofuran at 20;Inert atmosphere;chemoselective reaction;
References:
Zeng, Jing;Liu, Kun Ming;Duan, Xin Fang [Organic Letters,2013,vol. 15,# 20,p. 5342 - 5345] Location in patent:supporting information