5-(4-aminophenyl)-5-methylimidazolidine-2,4-dione synthesis

2synthesis methods

Product Name:5-(4-aminophenyl)-5-methylimidazolidine-2,4-dione
CAS Number:103273-09-2
Molecular formula:C10H11N3O2
Molecular Weight:205.21

5-METHYL-5-(4-NITRO-PHENYL)-IMIDAZOLIDINE-2,4-DIONE

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5-(4-aminophenyl)-5-methylimidazolidine-2,4-dione

103273-09-2
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Yield:-

Reaction Conditions:

with iron;ammonium chloride in methanol at 80; for 2 h;

Steps:

117 Synthesis of compound 117.3.

Synthesis of compound 117.3. To a solution of 117.2 (2.0g, 8.5mmol, 1.0 eq) in MeOH (3mL) and H₂0 (3 mL) was added NH₄C1 (2.25g, 42.5mmol, 5.0eq) followed by Fe powder (2. 4g, 42.5mmol, 5.0eq) for 1 hour. Reaction mixture was heated at 80 °C for 2 hours. Reaction mixture was filtered through celite, washed with methanol and obtained filtrate was concentrated under reduced pressure to get crude 117.3 (1.5g, 85.9 %) which was used as such for the next step, MS (ES): m/z 206.5 [M+H]⁺.

References:

WO2015/131080,2015,A1 Location in patent:Paragraph 00714; 00716

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References