ChemicalBook CAS DataBase List 5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE-2-T&

5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE-2-T& synthesis

11synthesis methods

Product Name:5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE-2-T&
CAS Number:23766-28-1
Molecular formula:C8H5ClN2OS
Molecular Weight:212.66

75-15-0
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536-40-3 Synthesis

536-40-3
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5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOLE-2-T&

23766-28-1
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$43.50/1g

Yield:23766-28-1 88.7%

Reaction Conditions:

with potassium hydroxide in methanol at 20 - 80; for 20 h;

Steps:

1.3 (3) Preparation of 5- (4-chlorophenyl) -1,3,4-oxadiazole-2-thiol

(8.79 mmol) of 4-chlorobenzoylhydrazide and 0.74 g (13.2 mmol) of potassium hydroxide were added to 50 mL of methanol, 0.8 mL (13.19 mmol) of carbon disulfide was added dropwise to the 100 mL round bottom flask at room temperature under stirring for 12 hours, and then was added 0.49 g (8.8 mmol) of potassium hydroxide, at an oil bath temperature of 80^Othe C was heated under reflux for 8 h, TLC analysis after the end of the reaction, the solvent was distilled off under reduced pressure, 30 mL of purified water was added, with 1M HCl to adjust the pH value of 2 to 3, a large number of system pale yellow solid precipitated, suction filtered, washed with water, dried, and recrystallized from ethanol to give a pale yellow solid 1.51 g, yield 88.7%,

References:

CN106008390,2016,A Location in patent:Paragraph 0016

75-15-0
241 suppliers
$40.00/100g