ChemicalBook CAS DataBase List 5-(4-Methoxyphenyl)-2-furoic acid

5-(4-Methoxyphenyl)-2-furoic acid synthesis

8synthesis methods

Product Name:5-(4-Methoxyphenyl)-2-furoic acid
CAS Number:52938-99-5
Molecular formula:C12H10O4
Molecular Weight:218.21

5-(4-METHOXYPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER

52939-05-6
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52938-99-5
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Yield:52938-99-5 100%

Reaction Conditions:

with methanol;sodium hydroxide for 3 h;Reflux;

Steps:

3.3 Step 3:

Step 3:Weigh 310 mg (1.11 mmol) of the intermediateMethyl 4- (4-methoxyphenyl) furan-2-carboxylic acid methyl ester was added dropwise to 1 mL of 4 mol / L NaOH solution in 5 mL of methanol and refluxed for 3 h. The reaction was cooled to room temperature, evaporated to dryness,10% dilute hydrochloric acid to adjust the pH to about 1, extracted with ethyl acetate 3 times, the organic phase, washed with saturated brine 2 times,Dried over anhydrous sodium sulfate and evaporated to give 290 mg of intermediate5- (4-trimethoxy) phenyl) furan-2-carboxylic acid in 100% yield.

References:

CN103992311,2017,B Location in patent:Paragraph 0103; 0128