ChemicalBook CAS DataBase List 5-(4-METHOXYPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL

5-(4-METHOXYPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL synthesis

10synthesis methods

Product Name:5-(4-METHOXYPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL
CAS Number:33901-36-9
Molecular formula:C9H9N3OS
Molecular Weight:207.25

4H-1,2,4-Triazole, 3-(4-methoxyphenyl)-4-(phenylmethyl)-5-[(phenylmethyl)thio]-

708245-91-4
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5-(4-METHOXYPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL

33901-36-9
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Yield:33901-36-9 93%

Reaction Conditions:

with aluminum (III) chloride in toluene at 60; for 4 h;

Steps:

3. General procedure for deprotection:

General procedure: To the solution of Suzuki-Miyaura cross-coupling product 8 (0.1 mmol, 1 eq) in toluene (5 mL)AlCl₃ (0.5 mmol, 5 eq) was added. The reaction mixture was heated at60 ^oC temperature for 4 h and poured into ice then extracted withEtOAc (3 x 10 mL). Organic layers were combined, washed with brine, dried overNa₂SO₄ and evaporated. Crude product 9 was purified by column chromatography on silica gel using PE:EtOAc (1:1) as eluent

References:

Katkevica, Sarmite;Salun, Pavlo;Jirgensons, Aigars [Tetrahedron Letters,2013,vol. 54,# 34,p. 4524 - 4525] Location in patent:supporting information