ChemicalBook CAS DataBase List 5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID

5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID synthesis

9synthesis methods

Product Name:5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID
CAS Number:40808-21-7
Molecular formula:C12H10O2S
Molecular Weight:218.27

5-(P-TOLYL)THIOPHENE-2-CARBOXYLICACIDMETHYLESTER,96%

50971-49-8
13 suppliers
$112.00/5g

5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID

40808-21-7
12 suppliers
$65.00/100mg

Yield:40808-21-7 94%

Reaction Conditions:

with methanol;sodium hydroxide for 3 h;Reflux;

Steps:

9.2 Step 2:

Weigh 330 mg (1.42 mmol) of the intermediateMethyl 5- (4-methylphenyl) thiophene-2-carboxylate was added dropwise to 1 mL of 4 mol / L NaOH solution in 5 mL of methanol and refluxed for 3 h. The reaction was cooled to room temperature,Add water dissolved with 10% dilute hydrochloric acid to adjust the pH value to about 1,Extracted three times with ethyl acetate, the combined organic phases were washed twice with saturated brine and anhydrous sulfurSodium sulfate dried and evaporated to dry290 mg of intermediate 5- (4-methylphenyl) thiophene-2-carboxylic acid in 94% yield.

References:

CN103992311,2017,B Location in patent:Paragraph 0103; 0181

7311-63-9 Synthesis