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5-(4-METHYLPHENYL)-3-METHYL-5-OXOVALERIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: sodium t-butanolate / tetrahydrofuran / 2 h / 0 °C
2: sodium hydroxide; water / tetrahydrofuran / 2 h

References:

Dagenais, Robin;Lussier, Tommy;Legault, Claude Y. [Organic Letters,2019,vol. 21,# 13,p. 5290 - 5294]