5,5-diMethyl-Proline synthesis

8synthesis methods

Product Name:5,5-diMethyl-Proline
CAS Number:146954-59-8
Molecular formula:C7H13NO2
Molecular Weight:143.18

65320-65-2
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Yield:146954-59-8 86%

Reaction Conditions:

with hydrogenchloride;waterReflux;

Steps:

22.C Step C. 5,5-dimethylpyrrolidine-2-carboxylic acid.

5,5-Dimethyl-pyrrolidine-2- carbonitrile (0.67 g, 5.4 mmol) was dissolved in 6 N HCl. The mixture was refluxed overnight and then concentrated under high vacuum. The residue was precipitated by Et₂0 to give the desired product (0.66 g, 86%). MS: 144 (M⁺+l).

References:

WO2013/107405,2013,A1 Location in patent:Page/Page column 107

ethyl 5,5-dimethyl-1-tosylpyrrolidine-2-carboxylate

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References

61856-88-0
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References

3317-61-1 Synthesis

3317-61-1
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References

2-Pyrrolidinecarbonitrile, 1-hydroxy-5,5-dimethyl-

61856-86-8
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References