ChemicalBook CAS DataBase List 5,6,7,8-TETRAHYDROQUINOLINONE-5

5,6,7,8-TETRAHYDROQUINOLINONE-5 synthesis

6synthesis methods

Product Name:5,6,7,8-TETRAHYDROQUINOLINONE-5
CAS Number:53400-41-2
Molecular formula:C9H9NO
Molecular Weight:147.17

10500-57-9
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$6.00/5g

53400-41-2
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$19.00/100mg

Yield:53400-41-2 77%

Reaction Conditions:

with tert.-butylhydroperoxide;manganese(II) triflate in water at 20; for 24 h;

Steps:

2 Example 2 Synthesis of 5,6,7,8-tetrahydroquinolin-5-one

0.883 mg of Mn (OTf) 2 (0.5 mol%), 67 mg of 5,6,7,8-tetrahydroquinoline, 0.35 g of a 65% aqueous TBHP solution, 2.5 ml of water, was added in turn to a 25 mL round bottom flask, in the air at room temperature for 24 hours, the reaction solution was extracted with 3 x 5 mL of ethyl acetate, the ethyl acetate layer was collected, dried over anhydrous sodium sulfate, filtered, evaporation of ethyl acetate, petroleum ether and ethyl acetate (5: 1, v / v) as the eluent, the product 5,6,7,8-tetrahydroquinolin-5-one (56.6 mg) was isolated by silica gel column chromatography, light yellow liquid, yield 77%.

References:

CN105669548,2016,A Location in patent:Paragraph 0029; 0030