5,6-DIAMINO-1-ISOPROPYLURACIL synthesis
- Product Name:5,6-DIAMINO-1-ISOPROPYLURACIL
- CAS Number:113885-21-5
- Molecular formula:C7H12N4O2
- Molecular Weight:184.2
113947-20-9
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113885-21-5
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Yield:113885-21-5 2.15 g
Reaction Conditions:
with hydrazine hydrate;sodium hydroxide at 0; for 1 h;
Steps:
Intermediate 8.1
To a mixture of 2.1 (2.5 g, 12.62 mmol) in NaOH (1 mol/L, 30 ml_, 30 mmol) hydrazine hydrate (1 .16 ml_, 23.34 mmol) was added and cooled to 0°C. Then raney nickel was added and the mixture was stirred for 1 h at 0°C. The mixture was cooled, acidified to a pH of 7-8 with cone. HCI, the obtained precipitate was filtered, washed with H2O (50 ml_) and tert-butylmethylether (50 ml_) and dried to obtain 2.15 g the product.MS (EST): (M+H)+ 185 HPLC: RT = 0.15 min, Method F
References:
WO2020/120450,2020,A1 Location in patent:Page/Page column 90
113885-20-4
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113885-21-5
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