5,6-dichloropyrazine-2,3-diamine synthesis

Yield:13484-57-6 32.4%

Reaction Conditions:

with ammonium hydroxide at 120; for 14 h;Sealed tube;

Steps:

32 5,6-dichloro-2,3-diaminepyrazine:

2,3,5,6-tetrachloropyrazine (2g, 9.6mmol) was added to a 100ml glass sealed tube, 40ml of concentrated ammonia water was added, stirred, heated to 120 ° C, 14h reaction, the reaction of the starting material was completely detected by TLC, with acetic acid The ethyl ester was extracted three times, washed with a saturated aqueous solution of sodium chloride, dried over sodium sulfate,A yellow solid 535 mg was obtained in a yield of 32.4%.

References:

CN108929280,2018,A Location in patent:Paragraph 0139; 0143; 0144