5,6-Dimethoxy-1,1-dimethyl-2,3-dihydro-1H-indene synthesis

7synthesis methods

Product Name:5,6-Dimethoxy-1,1-dimethyl-2,3-dihydro-1H-indene
CAS Number:51458-29-8
Molecular formula:C13H18O2
Molecular Weight:206.28

Benzenepropanol, 3,4-dimethoxy-α,α-dimethyl-

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5,6-Dimethoxy-1,1-dimethyl-2,3-dihydro-1H-indene

51458-29-8
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Yield:-

Reaction Conditions:

with sulfuric acid in water; for 0.5 h;Cooling with ice;

Steps:

11 Referential Example 11
Preparation of 3-(5,6-dimethoxy-3,3-dimethyl-2-indenyl)prop-(2E)-enoic acid

To 3.5 g (16 mmol) of 4-(3,4-dimethoxyphenyl)-2-methylbutan-2-ol cooled in an ice bath was added 20 ml (320 mmol) of 85% sulfuric acid chilled with ice, and the mixture was stirred for 30 minutes.. ice water was then added to the reaction mixture to conduct extraction with diethyl ether.. An organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and a saturated saline solution, dried over anhydrous sodium sulfate and then concentrated under reduced pressure, thereby obtaining 2.6 g of a crude oil containing 5,6-dimethoxy-1,1-dimethylindane.

References:

US6340682,2002,B1 Location in patent:Page column 43