5,7-Dichlorobenzofuran synthesis

4synthesis methods

Product Name:5,7-Dichlorobenzofuran
CAS Number:23145-06-4
Molecular formula:C8H4Cl2O
Molecular Weight:187.02

2,4-DICHLORO-1-(2,2-DIETHOXYETHOXY)BENZENE

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Yield:23145-06-4 30%

Reaction Conditions:

with tin-exchanged H-b zeolite (Sn-b) for 10 h;Reflux;

Steps:

3.3. General procedure for the synthesis of 2,3-unsubstitutedbenzo[b]furans

General procedure: A 25 mL round-bottomed flask was charged with 2-aryloxyacetaldehyde diethyl acetals (1 mmol), Sn-b (0.1 g), andtrifluorotoluene (10 mL). The mixture was stirred under refluxingcondition and monitored by GC. Upon completion, the mixture wascooled to room temperature, and the catalyst Sn-b was filtrate off.The filter cake was washed with trifluorotoluene (10 mL3). Thecombined filtratewas concentrated under vacuum. The residuewaspurified by flash column chromatography on SiO2 (petroleumether/ethyl acetate) to afford the desired 2,3-unsubstituted benzo[b]furans.

References:

Sun, Nan;Huang, Peng;Wang, Yifan;Mo, Weimin;Hu, Baoxiang;Shen, Zhenlu;Hu, Xinquan [Tetrahedron,2015,vol. 71,# 29,p. 4835 - 4841]

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23145-06-4
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References

2040-83-7 Synthesis

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120-83-2 Synthesis

120-83-2
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