ChemicalBook CAS DataBase List 5,8-DibroMoquinoxaline

5,8-DibroMoquinoxaline synthesis

6synthesis methods

Product Name:5,8-DibroMoquinoxaline
CAS Number:148231-12-3
Molecular formula:C8H4Br2N2
Molecular Weight:287.94

91-19-0
215 suppliers
$20.00/25g

148231-12-3
80 suppliers
$16.00/100mg

Yield: 75%

Reaction Conditions:

with bromine in acetonitrile for 25 h;Reflux;Inert atmosphere;

Steps:

4.1.1. General methods for high temperature bromination of quinoxaline and derivatives
General procedure: Bromine was added dropwise to a magnetically stirred refluxing solution of quinoxaline (1) or tetrahydroquinoxaline 15 or 19 in the relevant solvent. The resulting reaction mixture was heated at reflux temperature. The reaction was monitored by TLC or ¹H NMR spectroscopy. After the desired time, the resulting reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The mixture was diluted with a saturated solution of sodium carbonate (10mL) and the mixture was extracted with ethyl acetate (2×25mL). Combined organic layers were washed with water, dried over Na₂SO₄ and concentrated. The crude was purified appropriate method described in below.

References:

Uçar, Sefa;Eşsiz, Selçuk;Daştan, Arif [Tetrahedron,2017,vol. 73,# 12,p. 1618 - 1632]

131543-46-9 Synthesis