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ChemicalBook CAS DataBase List 5,8-DICHLOROISOQUINOLINE

5,8-DICHLOROISOQUINOLINE synthesis

6synthesis methods
-

Yield:73075-59-9 98%

Reaction Conditions:

Stage #1: isoquinolinewith sulfuric acid at 2 - 21; for 0.25 h;
Stage #2: 1,3-dichloro-5,5-dimethylhydantoin at 10 - 55; for 18.5 h;regioselective reaction;

References:

Walker, Matthew D.;Andrews, Benjamin I.;Burton, Andrew J.;Humphreys, Luke D.;Kelly, Gary;Schilling, Mark B.;Scott, Peter W. [Organic Process Research and Development,2010,vol. 14,# 1,p. 108 - 113] Location in patent:experimental part

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