ChemicalBook CAS DataBase List 5,8-dichloropyrazino[2,3-d]pyridazine

5,8-dichloropyrazino[2,3-d]pyridazine synthesis

2synthesis methods

Product Name:5,8-dichloropyrazino[2,3-d]pyridazine
CAS Number:13480-43-8
Molecular formula:C6H2Cl2N4
Molecular Weight:201.01

13480-40-5 Synthesis

6,7-DIHYDROPYRAZINO[2,3-D]PYRIDAZINE-5,8-DIONE

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Yield:13480-43-8 51%

Reaction Conditions:

with trichlorophosphate at 100; for 8 h;Inert atmosphere;

Steps:

7 Example 7: Synthesis of 5,8-Dichloropyrazino[2,3-D]pyridazine

Under nitrogen atmosphere, 0.1 mol of pyrazine dicarboxyl hydrazide,Dissolved in 150 mL of phosphorus oxychloride, heated at 100 degrees Celsius for 8 hours.After cooling to room temperature,Most of the unreacted phosphorus oxychloride was removed by rotary evaporation under reduced pressure.The pH of the solution was neutralized to 7 by dropwise addition of aqueous sodium bicarbonate solution, and a large amount of pale yellow precipitate was formed.After suction filtration, rinse with deionized water, and after drying, light yellow dichloride product 5,8-dichloropyrazino[2,3-D]pyridazine was obtained with a yield of 51%.

References:

CN113956295,2022,A Location in patent:Paragraph 0177-0183

4744-50-7 Synthesis

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References