ChemicalBook CAS DataBase List 5,8-Dioxaspiro[3.4]octane-2-Methanol

5,8-Dioxaspiro[3.4]octane-2-Methanol synthesis

7synthesis methods

Product Name:5,8-Dioxaspiro[3.4]octane-2-Methanol
CAS Number:545882-60-8
Molecular formula:C7H12O3
Molecular Weight:144.17

5,8-Dioxaspiro[3.4]octane, 2-[(phenylmethoxy)methyl]-

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Yield: 97%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol at 20; for 4 h;

Steps:

8.b.d
Step d: Preparation of 5,8-dioxaspiro[3.4]oct-2-ylmethanolPalladium/carbon (10 %) was added to a solution of 2-[(benzyloxy)methyl]-5,8- dioxaspiro[3.4]octane (22.0 gm, 94.0 mmol) (step c) in methanol and the mixture was stirred at room temperature under hydrogen balloon for about 4 hours. It was filtered through celite bed and residue was washed with methanol. The combined filtrate was concentrated under reduced pressure.Yield: 14.0 gm (97%)

References:

RANBAXY LABORATORIES LIMITED WO2008/111010, 2008, A1 Location in patent:Page/Page column 88