ChemicalBook CAS DataBase List 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE

5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE synthesis

8synthesis methods

Product Name:5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE
CAS Number:16019-33-3
Molecular formula:C6H4Cl2N2O
Molecular Weight:191.01

16019-31-1
74 suppliers
$12.00/100mg

16019-33-3
158 suppliers
$8.00/250mg

Yield:16019-33-3 88%

Reaction Conditions:

with ozone;triethylamine in dichloromethane;dimethyl sulfoxide at -40; for 0.5 h;Inert atmosphere;

Steps:

1.1.4 1.4 Synthesis of Compound II, 2-(4,6-Dichloropyrimidine)acetaldehyde
In a 50ml three-necked flask with magnetic stirring,Add 20ml of dichloromethane and 4,6-dichloro-5-allylpyrimidine(5.0 g, 0.026 mol), followed by the addition of dimethyl sulfoxide (8 g, 0.104 mol) and triethylamine (5.5 mL, 0.040 mol).Cool to -40 ° C, pass O3 until the reaction solution turns blue,Stop using O3 and switch to N2 for 30 minutes.Exclude O3 in the system.Add thiourea (2.0 g, 0.026 mol) and naturally raise to room temperature.Starch potassium iodide test paper detection (unchanged blue),Ensure that no peroxide is present in the reaction system. Add 60ml of water,The mixture was extracted twice with methylene chloride.The yield was 88%.

References:

East China Normal University;Shanghai Huanfu Industrial Co., Ltd.;Zhan Li;Zhu Haoting;He Yang;Li Xiaolin;Zhang Yuliu;Luo Yu;Zhang Wujun;Tang Meizhen CN108409745, 2018, A Location in patent:Paragraph 0038; 0040; 0043; 0046; 0048; 0049; 0052

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