ChemicalBook CAS DataBase List 5-ACETYL-2-INDOLE CARBOXYLIC ACID

5-ACETYL-2-INDOLE CARBOXYLIC ACID synthesis

4synthesis methods

Product Name:5-ACETYL-2-INDOLE CARBOXYLIC ACID
CAS Number:31380-57-1
Molecular formula:C11H9NO3
Molecular Weight:203.19

31380-56-0 Synthesis

31380-56-0
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1H-Indole-2-carboxylic acid, 3-acetyl-, ethyl ester

77069-10-4
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31380-57-1
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$350.00/500mg

105399-10-8
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Yield:31380-57-1 95% and 93%

Reaction Conditions:

with potassium hydroxide in ethanol;

Steps:

1 3-Acetyl-1H-indole-2-carboxylic acid (4b) and 5-Acetyl-1H-indole-2-carboxylic Acid (5b).

Saponification of 2b and 3b with 10% KOH in ethanol at 60° C. for 1 h followed by acidification with 1M HCl provided 3-acetyl-1H-indole-2-carboxylic acid 4b and 5-acetyl-1H-indole-2-carboxylic acid 5b in 95% and 93% yield respectively. The crude acids were used directly without purification in the next step.

References:

US2004/18986,2004,A1

127-17-3 Synthesis