5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-& synthesis
- Product Name:5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-&
- CAS Number:14678-93-4
- Molecular formula:C11H11N3O2
- Molecular Weight:217.22
15001-11-3
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$11.00/250mg
14678-93-4
38 suppliers
$23.89/1g
Yield:-
Reaction Conditions:
with water in ethanol;Reflux;
Steps:
2.4 General procedure for the synthesis of 5-amino-1-phenyl-1H-pyrazole-4-carboxylic acid derivatives (6)
General procedure: Intermediates 13 6 was synthesized according to the literature by ML Bender [28]. Intermediates 5 was dissolved in a solution of 15 ethanol and 16 potassium hydroxide and refluxed for 2h. After cooling, the pH of the mixture was adjusted to 5-6by the dropwise addition of 10% 17 HCl solution to give an intermediate 13 6, which was filtered under vacuum and recrystallized from ethanol to give the pure products.
References:
Liu, Hao;Ren, Zi-Li;Wang, Wei;Gong, Jie-Xiu;Chu, Ming-Jie;Ma, Quan-Wei;Wang, Jie-Chun;Lv, Xian-Hai [European Journal of Medicinal Chemistry,2018,vol. 157,p. 81 - 87]
539-44-6
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14678-93-4
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637-60-5
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$6.00/5g
14678-93-4
38 suppliers
$23.89/1g