ChemicalBook CAS DataBase List 5-Amino-1-methylindoline 97%

5-Amino-1-methylindoline 97% synthesis

4synthesis methods

Product Name:5-Amino-1-methylindoline 97%
CAS Number:64180-07-0
Molecular formula:C9H12N2
Molecular Weight:148.21

18711-25-6
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64180-07-0
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Yield:64180-07-0 72%

Reaction Conditions:

with tin(ll) chloride in ethyl acetate at 20;

Steps:

103.b

To a solution of l-methyl-5-nitro-2,3-dihydro-lH-indole (0.2g, 1.13mmol) in ethyl acetate (12ml) was added stannous chloride dihydrate (1.26g, 5.6mmol) and the reaction mixture was stirred overnight at room temperature. The reaction was then neutralized EPO with aqueous sodium hydroxide solution. The organic layer was separated, washed with water, dried, and then concentrated to oil. The crude compound was purified by column chromatography over silica gel using ethyl acetate/pet ether (1:1) as eluent to give 1- methyl-2,3-dihydro-lH-indol-5-ylamine (0.12g, 72%) as solid.

References:

WO2006/123145,2006,A1 Location in patent:Page/Page column 50-51

32692-19-6
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64180-07-0
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References

Benzenesulfonic acid, 4-[2-(2,3-dihydro-1-methyl-1H-indol-5-yl)diazenyl]-

106883-07-2
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64180-07-0
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References

824-21-5
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64180-07-0
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References