5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE synthesis

4synthesis methods

Product Name:5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE
CAS Number:61507-88-8
Molecular formula:C7H12N4O
Molecular Weight:168.2

107-10-8
354 suppliers
$10.00/20mg

6719-21-7 Synthesis

6719-21-7
115 suppliers
$35.00/500mg

149-73-5 Synthesis

149-73-5
521 suppliers
$12.00/5g

5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE

61507-88-8
9 suppliers
$220.00/1g

Yield:61507-88-8 61%

Reaction Conditions:

in acetonitrile;

Steps:

2 5-Amino-1-n-propylimidazole-4-carboxamide

PREPARATION 2 5-Amino-1-n-propylimidazole-4-carboxamide A mixture of 2-amino-2-cyanoacetamide (2.8 g, 0.0282 mol), trimethylorthoformate (3.4 g, 0.0321 mol) and acetonitrile (55 ml) was heated under reflux for 0.75 hour, then allowed to cool. n-Propylamine (1.8 g, 0.0305 mol) was then added dropwise, and the resulting mixture stirred at ambient temperature for 36 hours. The solid which precipitated was collected by filtration and crystallized from methanol to give the title compound as a colourless solid (2.9 g, 61%), m.p. 241°-243° C. Found: C,49.67; H,7.15; N,33.64. C₇ H₁₂ N₄ O requires C,49.98; H,7.19; N,33.31%.

References:

US5734053,1998,A

107-10-8
354 suppliers
$10.00/20mg